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Akpre Acne management made safe and simple


Composition

Each 30 g contains

Pippali (Piper longum) 300 mg
Methi (Trigonella foenum graecum) 30 mg
Witch hazel (Hamamelis virginiana) 30 mg
Garlic oil (Allium sativum) 30 mg
Clove oil (Syzygium aromaticum) 30 mg
Kumari (Aloe vera) 30 mg
Haldi (Curcuma longa) 0.95 mg
Wheat germ oil (Triticum sativum germ) 0.15 mg
Base Q.S


Phytochemistry

The active ingredients of Piper longum are E-Nisobutyl- eicosa-dienamide, E-Z-N-isobutyl-eicosa-trienamide, E-Z-Nisobutyl-ocatadeca-trienamide, guineensine, pipernonaline, pellitorine, piperine, piperanine, and piperlonguminine. The essential oil of Trigonella foenum-graecum contains n-alkanes, sesquiterpenes, alkanoles and lactones. Hamamelis virginiana contains Hamamelitannin and the galloylated proanthocyanidins.

Garlic contains allicin (diallyl disulphide oxide), which is produced enzymatically from alliin (S-2-propenyl-L-cysteine. In the essential oil from steam distillation, diallyl disulphide (60%) is found besides diallyl trisulphide (20%), diallyl sulfide, ajoene and minor amounts of other di- and polysulphides. Clove oil (Syzgium aromaticum) is dominated by eugenol (70 to 85%), eugenol acetate (15%) and β-caryophyllene (5 to 12%), which together make up 99% of the oil and about 2% of the triterpene oleanolic acid. The principle constituents of Aloe vera are anthraquinones (aloe-emodin and aloin A/barbalin), cinnamoyl, pcoumaroyl, feruloyl, caffeoyl aloesin, aloemannan, acemannan, verectin, elgonica dimer A and bisbenzopyran.

The principle ingredient of Curcuma longa are curcumin, curcuminoids (demethoxycurcumin, bisdemethoxycurcumin), and ar-turmerone. Triticum sativum contains significant amounts of iron, phosphorus, magnesium, manganese, copper and zinc; iodine and cobalt are present in trace amounts. Wheat germ is a good source of thiamin and nicotinic acid, a rich source of tocopherols with high vitamin-E potency and also contains small quantities of ergosterol and dihydroergosterol.


Clinical Pharmacology

Curcuma longa has anti-inflammatory, anti-bacterial, anti-fungal, anti-viral, anti-oxidant properties. Aloe vera has anti-histaminic, wound healing and immunostimulant properties. Trigonella foenum relieves boils and abscesses. Triticum sativum germ protects the skin from scavenging free-radicals, prevents premature aging and reduces UV rays induced damage. It helps in proper drainage of secretions from the sebaceous and other glands of the skin and thereby helps in preventing black heads. It also prevents ultraviolet damage. Hamamelis virginiana possesses anti-inflammatory, anesthetic and astringent properties. The anti-bacterial, anti-inflammatory, anti-oxidant, anaesthetic and astringent properties of Akpre helps both in prevention and treatment of first and second degree acne vulgaris.


Indications

Acne vulgaris.


Contraindications

Hypersensitivity to any of the ingredients.


Adverse Effects

None.


Special Precautions

Wash the face before use with clean water, pat dry with a clean towel and apply gently over the affected surface. Do not rub vigorously on the affected part.


Dosage

To be applied twice a day.


Presentation

30 gms collapsible tube.


References

1 Kim JE, Kim AR. Phytother Res. 2003 May; 17(5):481-4.
2 Song EK, Cho H. Planta Med. 2001 Dec; 67(9):876-7.
3 Kostalova D, Bezakova L. Ceska Slov Farm. 2004 Sep; 53(5): 248-51.
4 Zhongguo Zhong Yao Za Zhi. 2002 Apr;27(4):277-9.
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