 |
An effective and gentle gel for painful joints |
Composition
Each gram contains
| Gandhapura tel (Gaultheria fragrantissima) |
75 mg |
| Shallaki (Boswellia serrata) |
25 mg |
| Nilgiri tel (Eucalyptus globulus) |
25 mg |
| Nirgundi (Vitex negundo) |
5 mg |
| Base |
Q.S |
Phytochemistry
Gaultheria fragrantissima is a source of methyl salicylate. The principle constituents of
Boswellia serrata are acetyl 11- keto-beta boswellic acid, 11-keto beta-boswellic acid, acetyl betaboswellic acid and beta-boswellic acid
1. Cineole (62%) and pinene (24%) are the principal active constituents of the eucalyptus oil. The principal constituents of
Vitex negundo are casticin, isoorientin, chrysophenol D, luteolin, phydroxybenzoic acid, D- ructose, lignans (negundins A and B), diasyringaresinol, lyoniresinol, vitrofolal E, vitrofolal
2, and flavone (vitexicarpin)
3. The
Boerrhavia diffusa contains alkaloids (0.05%), triacontanol hentriacontane, ß-sitosterol, ursolic acid, 5,7-dihydroxy-3,4-dimethyoxy-6,8-dimethyl flavone, and an unidentified ketone (m p 86°). The roots contain the rotenoid boeravinones AI, BI, C2 , D, E and F besides the new dihydroisofurenoxanthin, borhavine and an anti-fibrinolytic agent, punarnavoside. Two lignans, liriodendrin and syringaresinol mono-ß-D-glucoside, have also been reported in the roots
4.
Clinical Pharmacology
Boswellia serrata has potent analgesic and anti-inflammatory activity. Boswellic acids from
Boswellia serrata enhance the catabolism of GAGs. Methyl salicylate (
Gaultheria fragrantissima) produces rubefacient action by causing dilation of the capillaries and an increase in blood circulation.
Eucalyptus globulus has analgesic, anti-neuralgic properties and increases blood circulation.
Boerrhavia diffusa has analgesic properties.
Indications
Osteoarthritis, lumbago, sprain, musculoskeletal pain and peripheral neuralgia.
Contraindications
There are no absolute contraindications in using Ostranil gel.
Adverse Effects
Ostranil gel has no adverse effect if applied in prescribed dosage.
Special Precautions
Ostranil gel should not be used by patients having hypersensitivity to any of its ingredients.
Ostranil gel should not be applied to open lesions or wounds.
Contact with eyes and mucous membranes should be avoided and younger children should not apply Ostranil gel by themselves.
Dosage
1-2 gms to be applied gently at the site of pain or as directed by the Physician.
Presentation
30g lamitube.
References
| 1 |
Pungle P, Banavalikar M. Indian J Exp Biol. 2003 Dec; 41(12): 1460-2. |
| 2 |
Azhar-Ul-Haq, Malik A. Chem Pharm Bull (Tokyo). 2004 Nov; 52(11): 1269-72. |
| 3 |
Diaz F, Chavez D. Nat Prod. 2003 Jun; 66(6): 865-7. |
| 4 |
Cooksley, V.G., 1996, Aromatherapy, Prentice Hall, New Jersey 07652. |
| 5 |
Harborne, J.B., 1999, Phytochemical Dictionary, Taylor and Francis Ltd., London. |