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Sepno Buy

Sepno A trustworthy immunomodulator


Composition

Each tablet contains

Shudh guggul (Boswellia serata) 155 mg
Maharasandi quath 141 mg
Guduchi (Tinospora cordifolia) 90 mg
Manjishta (Rubia cordifolia) 70 mg
Shankh bhasam 45 mg
Amla (Emblica officinalis) 40 mg
Sahan beej (Moringa oleifera) 40 mg
Yashtimadhu (Glycyrrhiza glabra) 14 mg


Phytochemistry

Guggulu contains guggulsterones. The active constituents of Tinospora cordifolia are diterpene glucosides (A - D) 1, cordioside, cordiofolioside (A - C) 2, cordiol, syringin 3, diterpene furanolactones tinosporide 4 and columbin 5. The principle constituents of Rubia cordifolia are hydroxyanthraquinones, gallic acid and tannins 6. The anti-bacterial constituents in Rubia cordifolia are alizarin, rubimallin, beta- sitosterol and daucostero 7. The active ingredients of Emblica officinalis are tannoids (emblicanin A & B, punigluconin, and pedunculagin) 8, pyrogallol 9, nonsesquiterpenoids, phenolics, proanthocyanidins 10. The active ingredients of Moringa olifera are pterygospermin, moringine and moringinine. The active ingredients of Glycyrrhiza glabra are glabridin and glabrene, licochalcone A, licoricidin and licoisoflavone B, isoflavonoids (3-arylcoumarin, pterocarpan, & isoflavan), gancaonols, vestitol, licoricone, 1- methoxyphaseollidin, glycyrin, formononetin, isolicoflavonol, glyasperin D, 6,8-diprenylorobol, gancaonin I, dihydrolicoisoflavone A 11, bioflavonoids (glabranin, pinocembrin, licoflavone, & wighteone) 12, licoagrodin, prenylated retrochalcones, licoagrochalcones B, C, D, licoagroaurone and flavonoids, licochalcone C, kanzonol Y, glyinflanin B and glycyrdione A, isoflavone glycoside, licoagroside (A & B) 13, a prenylated flavanone, licoleafol, a prenylated dihydrostilbenes, uralstilbene, 8-dimethylallyleriodictyol, sophoraflavanone B, gancaonin R, and 6-dimethylallyleriodictyol 14, glabrizoflavone 15, isoliquiritigenin 16 and aglycone beta-glycyrrhetinic acid 17.


Clinical Pharmacology

Sepno has immunomodulatory, anti-oxidant, anti-inflammatory, anti-microbial, anti-cancer, anti-tumor and anti-mutagenic actions.

Guggulu has anti-inflammatory and potent anti-oxidant actions. Tinospora cordifolia has potent immunomodulatory and immunostimulatory activities, which increases levels of antibodies and activates macrophages. Rubia cordifolia has potent anti-bacterial activity. Emblica officinalis has potent immnomodulatory and anti-oxidant actions. Glycyrrhizin from Glycyrrhiza glabra exhibits potent anti-viral activity. Moringa olifera has anti-viral, anti-inflammatory and anti-bacterial properties. Glycyrrhiza glabra remarkably potentiates reticuloendothelial system and enhances immunostimulation.

Sepno by the virtue of its immunoboosters, enhances both humoral and cell meidated immunity. The use of Sepno prevents infection in children which is usually triggered by the changing seasons. Sepno syrup and tablet prevents recurrent infections. Sepno is safe for long-term use. Sepno syrup also reduces the duration and cost of antibiotic therapy. It is a safe and effective adjuvant to anti-microbial therapy.


Indications

Recurrent infections.


Contraindications

There are no absolute contraindications for the use of Sepno.


Adverse Effects

Sepno is not known to have any adverse effects if taken in prescribed dosage.


Special Precautions

None.


Dosage

Initially 2 tablets twice daily followed by 1 tablet with luke warm water.


Presentation

Container of 60 tablets.


References

1 Maurya R, Manhas LR. Phytochemistry. 2004 Jul; 65(14): 2051-5.
2 Gangan VD, Pradhan P. Phytochemistry. 1994 Oct; 37(3): 781-6.
3 Kapil A, Sharma S. J Ethnopharmacol. 1997 Oct; 58(2): 89-95.
4 Swaminathan K, Sinha U C. Acta Crystallogr C. 1989 Jan 15; 45 (Pt 1): 134-6.
5 Cai Y, Sun M. J Agric Food Chem. 2004 Dec 29;52(26): 7884-90.
6 Qiao Y F, Wang SX. Yao Xue Xue Bao. 1990; 25(11): 834-9.
7 Bhattacharya A, Ghosal S. Indian J Exp Biol. 2000 Sep; 38(9): 877-80.
8 Khan MT, Lampronti I, Martello D. Int J Oncol. 2002 Jul; 21(1): 187-92.
9 Zhang YJ, Nagao T. Biol Pharm Bull. 2004 Feb; 27(2): 251-5.
10 Fukai T, Marumo A. Life Sci. 2002 Aug 9; 71(12): 1449-63.
11 Biondi DM, Rocco C. J Nat Prod. 2003 Apr; 66(4): 477-80.
12 Li W, Asada Y. Phytochemistry. 2000 Nov; 55(5): 447-56.
13 Hayashi H, Zhang SL. Chem Pharm Bull (Tokyo). 2003 Oct; 51(10): 1147-52.
14 Iuldashev MP, Batirov EKh. Bioorg Khim. 2000 Nov; 26(11): 873-6.
15 Kanazawa M, Satomi Y. Eur Urol. 2003 May; 43(5): 580-6.
16 Kroes BH, Beukelman CJ. Immunology. 1997 Jan; 90(1): 115-20.
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